Removal of non-tumorous ovaries in anti-N-methyl-D-aspartate receptor encephalitis. Report of 2 cases and literature review

Ana L. Calderón-Garcidueñas, Department of Neuropathology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico
Diego I. Talavera-Bazán, Department of Neuropathology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a form of autoimmune limbic encephalitis mediated by antibodies against the GluN1 (or NR1) subunit of the NMDAR. It is associated up to 56% with the presence of teratomas. Based on two cases, we analyze the literature that supports the use of oophorectomy when evidence of neoplasia by imaging is lacking.

Keywords: N-methyl-D-aspartate receptor encephalitis. Limbic encephalitis. Bilateral oophorectomy. Clinical evolution.