Ricardo E. Ramírez-Orozco, Nutrition Department, Universidad Autónoma de Aguascalientes, Ags., Mexico
Yancarlo Ojeda-Aguilar, Psychology Department, Universidad Autónoma de Aguascalientes, Ags., Mexico
Karina A. Pedroza-García, Nutrition Department, Universidad Autónoma de Aguascalientes, Ags., Mexico
David Masuoka, Stomatology Department, Universidad Autónoma de Aguascalientes, Ags., Mexico
Judith Martín del Campo-Cervantes, Nutrition Department, Universidad Autónoma de Aguascalientes, Ags., Mexico
Denisse Calderón-Vallejo, Morphology Department. Universidad Autónoma de Aguascalientes, Ags., Mexico
Background: Obesity is a significant problem that has been increasingly associated with the development of various morbidities in recent decades. The composition of nutrients in the diet and their interactions can serve as potential mediators within the endocannabinoid system, playing a role in these conditions. These may include anxiety, depression, nutritional imbalances, among others. Objective: To evaluate the effect of the lipoamino acids N-arachidonoyl glycine (NAGly) and N-oleoyl glycine (OlGly) on neurotransmission related to appetite and behavior, weight, and fat tissue. Method: Forty-twoC57BL/6 mice were assigned to six groups according to diet and treatment. NAGly or OlGly was administered for 7 days.Weight, fat mass, serotonin, and brain-derived neurotrophic factor were evaluated, along with anxiety-related behavioral tests. Results: The OlGly group developed more significant weight gain and body fat, and all groups treated with lipoamino acidsshowed lower serotonin levels. Finally, the NAGly and OlGly groups showed lower locomotion, decreasing their motor activityin the open field test. Dietary factors and possible mediators, such as lipoamino acids, can interact, contributing to the appearance of alterations in the development of obesity comorbidities. Further studies would be crucial to improve our understanding of the complexity of this condition. Conclusion: The complex nature of obesity and its interactions with thesemolecules that may participate and mediate in endocannabinoid system processes demands further research into dietaryfactors and their effects on health.
Keywords: N-arachidonoyl glycine. N-oleoyl glycine. Serotonin. Brain-derived neurotrophic factor. Fat tissue. Anxiety-like behavior.